How can we create systems and structures that empower students with the biggest learning gaps to learn and retain critical content? This workshop explored the transformative concept of neuroplasticity—how the brain adapts to systems, structures, and functions in response to experiences. Participants delved into cognitive learning structures and best practices for how the brain acquires, processes, and retains information. This session provided actionable strategies to frame effective learning experiences and implement systems that foster enduring academic growth for all students.